Digital Nanopore Sequencer

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Project 3 – Digital Nanopore Sequener

The aim of Project P3 is to develop a so-called “Interactome Profiler”.
The interactome refers to the entire network of molecular interactions within a cell. The profiler is intended to provide insight into how the epigenetic modifications of individual molecules affect the interactome.

Experimental Setup

By using a highly parallel arrangement of individual nanopores and digital readout, disease-associated epigenetic factors can be analysed, such as DNA methylation and post-translational modifications of proteins. We will characterise T cells enriched from blood and so-called extracellular vesicles (EVs) for epigenetic changes. In doing so, we aim to identify promising biomarker candidates and thus lay the foundation for the future use of nanopores in liquid biopsy-based diagnostics.

Analytical Device

Already in the first implementation phase, a range of products and services are expected to be developed, along with methods that can be independently marketed in implementation phases 2 and 3.

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