On 8 November 2024, RWTH Aachen University hosted the science night “5 to 12” – an inspiring evening that brought science to life for everyone. A week later, on the Biotechnology Open Day, the next opportunity arose to take a closer look at groundbreaking research. The team led by Prof. Maria Fyta showcased their work as part of the nanodiag BW project.
Using computer simulations, the Aachen researchers study nanopore materials and how they can be employed to detect DNA and proteins. They leverage machine learning to evaluate signals from nanopores and develop protocols for analysis.
To make the complex principles of nanopore sensing more comprehensible, the team designed an interactive model: small chains of beads, representing DNA and protein molecules, floated in a water tank. Visitors could create a current using a built-in water pump to guide the chains through a hole – a simplified version of a nanopore.
This experiment vividly illustrated the interplay between research and application, sparking curiosity about biotechnological questions.
Nanopore sensing is a technology that uses tiny pores at the molecular or nanometric scale to detect and analyse biomolecular substances such as DNA or proteins. In the laboratory, an electrical signal is measured as molecules pass through a pore. Differences in the size, shape, or charge of the molecules generate characteristic signals, which can be used for identification or quantification.
Cornhole Game as a Crowd-Puller
Another highlight in Aachen, alongside the water tank experiment, was the nanodiag BW cornhole game. This playful approach to science attracted many guests and created a lively atmosphere. With a diverse and engaging programme, both events became a resounding success. The positive feedback demonstrated that young people can be inspired by innovative solutions to pressing issues such as health diagnostics. The future of biotechnology begins with committed talents shaping the science of tomorrow.
That’s why nanodiag BW focuses on creative initiatives in STEM youth development, aiming to spark and sustainably foster the spirit of discovery in the next generation.